This study applied the thermoelectric chip design and the establishment of the personalized air-conditioning system in the design of the single duct and double duct structures. According to the actual measurement results when the ambient temperature was 29°C, the air outlet temperature of the two structures was 22°C, 24°C respectively; the power consumption was 133W, 134W respectively. FLUENT was used to simulate the spatial flow field and temperature field for comparison to learn about the spatial temperature distribution status of the air-conditioning system.