Dental air turbine handpieces have been widely used in clinical dentistry for over 30 years, however, little work has been reported on their performance. In dental air turbine handpieces, the types of flow channel and turbine blade shape can have very different designs. These different designs can have major influence on the torque, rotating speed, and power performance. This research is focused on the turbine blade and the flow channel designs. Using numerical simulation and experiments, the key design parameters which influence the performance of dental hand pieces can be studied. Three types of dental air turbine designs with different turbine blades, nozzle angles, nozzle flow channels, and shroud clearances were tested and analyzed. Very good agreement was demonstrated between the numerical simulation analyses and the experiments. Using the analytical model, parametric studies were performed to identify key design parameters.